Polynucleotide Treatments

Advanced Skin Regeneration Backed by Science

Polynucleotide (PN) treatments are an innovative, regenerative skincare option designed to stimulate deep healing, hydration, and cellular renewal. Originally developed in medical and wound care settings, polynucleotides are now a powerful tool in aesthetics, offering natural, biocompatible solutions for skin rejuvenation.

What Are Polynucleotides?

Polynucleotides are purified fragments of DNA taken from natural sources (usually salmon or trout). Because they closely resemble human DNA, they are safe and well-tolerated by the body.

Instead of adding volume like traditional fillers, polynucleotides work by stimulating your skin to repair and rebuild itself. They help your skin become healthier, firmer, and more hydrated using your body's natural healing abilities. They are often called regenerative injectables because they encourage long-term improvements in skin quality.

How Do Polynucleotides Work?

1. They Wake Up Your Skin's Collagen Factories

Polynucleotides boost the activity of fibroblasts — the cells in your skin that produce collagen and elastin. These are the proteins that keep skin firm, elastic, and youthful.

Helps with:

·       Fine lines and wrinkles

·       Loose or sagging skin

·       Loss of skin firmness

2. They Deeply Hydrate the Skin

Polynucleotides improve your skin's hydration levels by supporting the production of natural substances like hyaluronic acid, which holds water in the skin and gives it a fresh, plump look.

Helps with:

·       Dehydrated or dry skin

·       Thin, crepey skin

·       Under-eye hollowness or tired appearance

3. They Improve Blood Flow

These treatments help grow tiny new blood vessels in the skin, bringing more oxygen and nutrients to the area. This helps the skin heal, look brighter, and feel more alive.

Helps with:

·       Dark circles under the eyes

·       Dull or tired-looking skin

·       Slow healing or sluggish skin

4. They Calm Inflammation and Fight Free Radicals

Polynucleotides act as antioxidants, helping to protect the skin from damage caused by pollution, stress, and UV rays. They also reduce inflammation, making them ideal for sensitive or red-prone skin.

Helps with:

·       Redness or rosacea

·       Irritated or sensitive skin

·       Pigmentation caused by inflammation

5. They Help Improve Scars

Specific polynucleotide products (like Rejuran S) are designed to help remodel scar tissue. They break down abnormal scar fibres and guide the skin to build smoother, healthier collagen in its place.

Helps with:

·       Acne scars (especially depressed or textured scars)

·       Uneven skin texture

·       Scars from surgery or trauma

6. They Support Skin Repair at the DNA Level

Polynucleotides provide the building blocks your skin needs to repair damaged cells and replace them with healthier ones. This is especially helpful for skin that has been affected by sun exposure, ageing, or environmental stress.

Helps with:

·       Sun-damaged or photoaged skin

·       Pigmentation and uneven tone

·       Tired, stressed skin

Where Can They Be Used?

Face (General Rejuvenation)

Products used: Plinest Fast, Phenylage XL, Nucleofill, Rejuran HB
Targets fine lines, dullness, and loss of firmness by improving skin texture, elasticity, and hydration from within. Rejuran HB also adds deep hydration for sensitive or dry skin.

Under-Eye Area

Products used: Rejuran I, Plinest Eye, Vitaran I
Designed to improve dark circles, fine lines, and thinning by boosting circulation and collagen in the delicate under-eye area.

Acne Scarring

Product used: Rejuran S
Helps repair and smooth atrophic (indented) acne scars by promoting healthy skin remodelling and collagen production.

Neck

Products used: Phenylage XL, Nucleofill
Improves crepiness, laxity, and neck lines with skin tightening and hydration effects.

Hands

Product used: Phenylage XL
Restores skin thickness, elasticity, and brightness in the hands, which are often prone to early signs of ageing.

Treatment Protocols

·       A course of 2 to 3 treatments spaced 4 to 5 weeks apart is typically recommended for optimal results.

·       Maintenance treatments may be performed every 4 to 6 months, depending on skin condition and goals.

·       A full consultation is carried out before the first treatment to assess suitability and customise your protocol.

What to Expect During the Procedure

·       The treatment area is cleaned and prepped with a topical anaesthetic if needed.

·       Small amounts of product are injected using fine needles or cannulas.

·       The procedure typically takes 30 to 45 minutes.

·       Most patients report only mild discomfort.

Downtime and Aftercare

·       Mild redness, swelling, or bruising at injection sites is common and usually resolves within 24 to 72 hours.

·       You can resume most normal activities immediately after treatment.

·       Avoid intense exercise, heat exposure, or alcohol for 24 hours post-treatment.

·       Full results develop gradually over a few weeks as collagen production increases.A full medical consultation will be carried out to assess your suitability and ensure treatment safety.

Ready to Renew Your Skin from Within?

Book a consultation to see how polynucleotide therapy can help you achieve glowing, resilient skin — naturally.

Cost

Each session is priced at £200.

Package deals may be available for multi-session bookings.

Polynucleotides

  • What they do: Stimulate natural skin repair
  • Results: Gradual, long-term improvement
  • Good for: Improving skin quality, hydration, scars
  • How long they last: Results improve over time with repeat sessions
  • Look and feel: Natural, subtle, regenerative

Skin Boosters

  • What they do: Hydrate and improve skin texture
  • Results: Moderate, visible hydration boost
  • Good for: Dehydrated or dull skin, fine lines
  • How long they last: Typically 3–6 months
  • Look and feel: Refreshed, hydrated, radiant

Dermal Fillers

  • What they do: Add volume to specific areas
  • Results: Immediate but temporary plumpness
  • Good for: Filling deep lines, adding contour
  • How long they last: Slowly dissolve over 6–18 months
  • Look and feel: Sculpted and volumised

Contraindications

Polynucleotide treatments are generally very safe and well-tolerated. However, they may not be suitable for everyone. You should not receive this treatment if you:

·       Are allergic to fish or shellfish (as the DNA is often derived from salmon or trout)

·       Are pregnant or breastfeeding

·       Have active skin infections or severe inflammation in the treatment area

·       Have a known autoimmune condition affecting the skin (unless cleared by your clinician)

·       Are undergoing chemotherapy or immunosuppressive treatment

·       Have a history of severe allergic reactions (anaphylaxis)

A full medical consultation will be carried out to assess your suitability and ensure treatment safety.